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What is hydrocodone with acetaminophen?
Hydrocodone with acetaminophen is a tablet or liquid that contains two different types of medicine. Hydrocodone is an opioid medicine used to treat pain. Acetaminophen (Tylenol®) is a medicine used to treat pain or fever. Hydrocodone with acetaminophen is available as a tablet or liquid form in multiple strengths and multiple brand names. All are taken by mouth.
Tablets:
- Hydrocodone 5 mg/Acetaminophen 300 mg
- Hydrocodone 10 mg/Acetaminophen 300 mg
Liquid:
- Hydrocodone 7.5mg/Acetaminophen 325 mg in 15 ml
- Common Brand Names: Lortab®, Vicodin®, Lorcet®, Norco®, Xodol®
Possible side effects of hydrocodone with acetaminophen
Early
- Feeling drowsy
- Nausea
- Slower than normal rates of breathing
- Low blood pressure
Later (more than a day after treatment starts)
- Constipation (hard to have bowel movement)
- Itching and hives
- Feeling drowsy or very sleepy
- Feeling dizzy
- Nausea and vomiting
- Mood changes (feeling sadder or happier)
- Dry mouth
- Fainting
- Problems urinating
- Liver damage
Special instructions for hydrocodone with acetaminophen
- If you have any of the side effects listed above, most should get better after you have taken hydrocodone with acetaminophen for a few days. Tell your doctor if the side effects get worse while you are taking this medicine. It may mean you need less medicine.
- This medicine may cause you to feel dizzy and drowsy. Do not operate heavy equipment or drive a car until you see how this medicine affects you.
- If you have not slept well because of your pain, you may sleep more during the first few days of taking this medicine to “catch up” on missed sleep.
- If you are taking this medicine regularly, then you should drink more fluids and eat more fiber to help prevent constipation.Buy Hydrocodone 10/660mg tablet
- Tell your doctor or nurse if you have not had a bowel movement in 3 to 5 days. You may need to take a stool softener or laxative to relieve your constipation.
- If you are taking this medicine on a regular basis, do not stop taking it until the doctor tells you to do so.
- If you have taken hydrocodone with acetaminophen for a long time, at some point your doctor will slowly decrease your dose to wean you off the medicine.Buy Hydrocodone 10/660mg tablet
- During this time, watch for a sudden onset of diarrhea, headache, sweating, muscle cramps, nausea, vomiting, or trouble sleeping and resting. If this occurs, call your doctor right away. It could mean your dose is being lowered too fast.
- Do not take acetaminophen (Tylenol®) while taking hydrocodone with acetaminophen. Taking both medicines at the same time could result in a Tylenol® dose that is too high.Buy Hydrocodone 10/660mg tablet
- Acetaminophen (Tylenol®) is found in many over-the-counter products. Read labels carefully and ask your doctor or pharmacist if it is safe to start a new medicine.Buy Hydrocodone 10/660mg tablet
- Other medicines can increase the drowsy feeling caused by hydrocodone with acetaminophen. These include:
- Alcohol (found in many over-the-counter cough and cold medicines)
- Diphenhydramine (over-the-counter Benadryl®)
- Promethazine
- Diazepam or lorazepam
- Antidepressants, such as amitriptyline
- Medicines used to treat seizures (such as carbamazepine, phenytoin, gabapentin, phenobarbital, and valproic acid)
- Always tell your doctor if you are taking any of these medicines, or if you start taking any new medicine while you are taking hydrocodone with acetaminophen.Buy Hydrocodone 10/660mg tablet
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other opioids (such as benzhydrocodone, hydromorphone, morphine, codeine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
- brain disorders (such as head injury, tumor, seizures)
- breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD)
- kidney disease
- liver disease
- mental/mood disorders (such as confusion, depression, thoughts of suicide)
- personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol)
- stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus)
- difficulty urinating (such as due to enlarged prostate)
- gallbladder disease
- disease of the pancreas (pancreatitis)
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Liquid products may contain sugar and alcohol. Caution is advised if you have diabetes, alcohol dependence, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Children may be more sensitive to the side effects of this drug, especially slow/shallow breathing.
Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, and slow/shallow breathing.
During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.
This medication passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug are:
- certain pain medications (mixed opioid agonist/antagonists such as butorphanol, nalbuphine, pentazocine)
- naltrexone
- samidorphan
The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Buy Hydrocodone 10/660mg tablet
Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, oxycodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.Buy Hydrocodone 10/660mg tablet
Other medications can affect the removal of hydrocodone/acetaminophen from your body, which may affect how hydrocodone/acetaminophen works. Examples include azole antifungals (such as ketoconazole), macrolide antibiotics (such as erythromycin), levoketoconazole, mifepristone, HIV medications (such as tipranavir), rifamycins (such as rifabutin, rifampin), ritonavir, certain drugs used to treat seizures (such as carbamazepine, phenytoin), among others.
This medication may interfere with certain lab tests (such as amylase/lipase levels), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.Buy Hydrocodone 10/660mg tablet
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